Scanning Electrochemical Microscopy of DNA Monolayers Modified with Nile Blue

Scanning electrochemical microscopy of DNA monolayers modified with Nile Blue.

Scanning electrochemical microscopy (SECM) is used to probe long-range charge transport (CT) through DNA monolayers containing the redox-active Nile Blue (NB) intercalator covalently affixed at a specific location in the DNA film. At substrate potentials negative of the formal potential of covalently attached NB, the electrocatalytic reduction of Fe(CN)6(3-) generated at the SECM tip is observe...

Seeing big with scanning electrochemical microscopy.

Full Text HTML Hi-Res PDF [1123K] PDF w/ Links [855K] Subscriber Access MPIC: A High-Throughput Analytical Method for Multiple DNA Targets Jinchao Guo, Litao Yang, Lili Chen, Dany Morisset, Xiang Li, Liangwen Pan, and Dabing Zhang pp 1579–1586 Publication Date (Web): February 3, 2011 (Article) DOI: 10.1021/ac103266w Abstract | Supporting Info| Supporting Info Full Text HTML Hi-Res PDF [4330K] P...

Scanning electrochemical microscopy. 51. Studies of self-assembled monolayers of DNA in the absence and presence of metal ions.

Scanning electrochemical microscopy was used to examine electron transfer across a self-assembled monolayer of thiol-modified DNA duplexes on a gold electrode. The apparent rate constant for heterogeneous ET from a solution redox probe, Fe(CN)6(3-/4-), to the gold surface through ds-DNA was 4.6 (+/-0.2) x 10(-7) cm/s. With the addition of Zn2+, which resulted in the formation of a metalated DNA...

Keysight Technologies Combining Atomic Force Microscopy with Scanning Electrochemical Microscopy

Silver-Enhanced Imaging of DNA Hybridization at DNA Microarrays with Scanning Electrochemical Microscopy

The use of scanning electrochemical microscopy (SECM) to image oligodeoxynucleotide (ODN) hybridization at spots on microarrays has been demonstrated. ODN probes at a microarray surface were hybridized with a biotinylated target, and the regions where sequence-specific hybridization had occurred were developed by the silver staining process (adsorption of streptavidin-gold nanoparticles followe...